H3.1Cys96 oxidation by mitochondrial ROS promotes chromatin remodeling, breast cancer progression to metastasis and multi-drug resistance
F. R. Palma, F. T. Ogata, D. R. Coelho, K. Pulakanti, A. Meyer, Y. Huang, J. M. Daves, M. J. Schipma, C. M. Furdui, D. R. Spitz, B. N. Gantner, S. Rao, V. Backman, M. G. Bonini
The paper shows that mitochondrial H2O2 oxidizes H3.1 at Cys96, promoting chromatin remodeling, breast cancer metastasis, and drug resistance.
bioRxiv · Dec 1, 2022 · PreprintCancer Biology