M. J. Schipma

Novel antibody language model accelerates IgG screening and design for broad-spectrum antiviral therapy

This paper introduces an antibody language model (AbLM) to accelerate IgG screening and design for broad-spectrum antiviral therapy, achieving higher precision in predicting variant-resistant antibodies.

H3.1Cys96 oxidation by mitochondrial ROS promotes chromatin remodeling, breast cancer progression to metastasis and multi-drug resistance

The paper shows that mitochondrial H2O2 oxidizes H3.1 at Cys96, promoting chromatin remodeling, breast cancer metastasis, and drug resistance.

CD81 partners with CD44 in promoting exosome biogenesis, tumor cluster formation, and lung metastasis in triple negative breast cancer

Tumor expressed CD95 causes suppression of anti-tumor activity of NK cells in a model of triple negative breast cancer

This study shows that CD95 expression by tumor cells suppresses NK cell anti-tumor activity in triple negative breast cancer, leading to reduced tumor growth in immune-competent mice.

The Cyclic AMP Receptor Protein Regulates Quorum Sensing and Global Gene Expression in Yersinia pestis During Planktonic Growth and Growth in Biofilms

This study identifies Crp-regulated genes in Y. pestis during planktonic and biofilm growth, revealing its role in quorum sensing, carbon metabolism, and virulence.

6mer seed toxicity in viral microRNAs

The paper identifies 6mer seed toxicity in viral miRNAs, showing some v-miRNAs kill cells via G-rich 6mer sequences, unlike most cellular miRNAs.

The oncogenic Kaposi sarcoma-associated herpesvirus encodes a mimic of the tumor suppressive miR-15/16 miRNA family

This study identifies KSHV miR-K6-5p as a functional mimic of the tumor suppressive miR-15/16 family, showing it inhibits cell cycle progression and promotes growth in KSHV-transformed B cells.