Author

B. Paudel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:fluorescence / live-cell microscopy· 3 Research Focus:protein folding & dynamics· 3 Approach:biophysical modeling· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:microscopy & imaging analysis· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. M. van Oijen· 2 shared A. van Oijen· 2 shared H. Ecroyd· 2 shared A. E. Murmann· 1 shared A. Silva· 1 shared C. Deshpande· 1 shared C. L. Johnston· 1 shared E. A. Wood· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBiochemistry

A. M. van Oijen

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Author profile →

5 papers

Recent·Most cited

The role of auxiliary domains in modulating CHD4 activity suggests mechanistic commonality between enzyme families

Y. Zhong, H. Moghaddas Sani, B. Paudel, J. Low, A. Silva, S. Mueller, C. Deshpande, S. Panjikar, X. Reid, M. Bedward, A. van Oijen, J. Mackay

The paper investigates how auxiliary domains in CHD4 modulate its activity, revealing common regulatory mechanisms across chromatin remodelling enzyme families.

bioRxiv · Jun 13, 2022 · PreprintBiochemistry

Real-time single-molecule observation of chaperone-assisted protein folding

N. Marzano, B. Paudel, A. van Oijen, H. Ecroyd

This study uses single-molecule techniques to observe Hsp70 chaperone interactions during protein folding, revealing binding cycles and distinct mechanisms for DnaJ and DnaK.

bioRxiv · May 9, 2022Biochemistry

Identification of the toxic 6mer seed consensus in human cancer cells

M. Patel, E. T. Bartom, B. Paudel, M. Kocherginsky, K. L. O'Shea, A. E. Murmann, M. E. Peter

The paper identifies GGGGGC as the most toxic 6mer seed in human cancer cells, confirming its mechanism through targeted gene disruption and reporter assays.

bioRxiv · Dec 22, 2020Cancer Biology

Single-molecule fluorescence-based approach reveals novel mechanistic insights into small heat shock protein chaperone function

C. L. Johnston, N. R. Marzano, B. Paudel, G. Wright, J. L. P. Benesch, A. M. van Oijen, H. Ecroyd

This study uses single-molecule fluorescence to reveal a two-step mechanism by which human Bc (HSPB5) interacts with misfolded proteins to prevent aggregation.

bioRxiv · Feb 16, 2020Biochemistry

Spatial and temporal organization of RecA in the Escherichia coli DNA-damage response

H. Ghodke, B. Paudel, J. S. Lewis, S. Jergic, K. Gopal, Z. J. Romero, E. A. Wood, R. Woodgate, M. M. Cox, A. M. van Oijen

This study uses a fluorescent probe to track RecA dynamics in live E. coli, showing it is stored during normal metabolism and rapidly mobilizes to form SOS-signaling complexes upon DNA damage.

bioRxiv · Sep 10, 2018Biophysics