J. S. Lewis

NaV1.7 targeted fluorescence imaging agents for nerve identification during intraoperative procedures

This paper develops fluorescent imaging agents targeting NaV1.7 to improve nerve visualization during surgery, demonstrating effectiveness in non-human primates.

Radiances of Cerenkov-Emitting Isotopes on the IVIS

The paper presents the largest experimental dataset of Cerenkov-emitting isotopes measured using IVIS, providing normalized radiance values for 21 isotopes across various emissions.

Preclinical shortwave infrared tumor screening and resection via pHLIP ICG under ambient lighting conditions

This study demonstrates that SWIR imaging with pHLIP ICG enables sensitive tumor detection and resection under ambient lighting conditions in a preclinical breast cancer model.

Vomocytosis of Cryptococcus neoformans cells from murine, bone marrow-derived dendritic cells

This study shows that Cryptococcus neoformans can be expelled from murine bone marrow-derived dendritic cells via vomocytosis, similar to macrophages, and is inhibited by phagosome and actin-modifying drugs.

Caveolin-1 temporal modulation enhances trastuzumab and trastuzumab-drug conjugate efficacy in heterogeneous gastric cancer

This paper identifies CAV1 as a biomarker for trastuzumab efficacy in HER2-positive gastric cancer and shows that statin use enhances antibody therapy response.

The E. coli helicase does not use ATP during replication.

The paper shows that the E. coli DnaB helicase does not use ATP during DNA replication, with polymerase-driven nucleotide incorporation providing the energy instead.

DETECTION OF INCIPIENT PANCREATIC CANCER WITH NOVEL TUMOR-SPECIFIC ANTIBODIES IN MOUSE MODELS

This study develops tumor-specific antibodies for early detection of pancreatic cancer using PET imaging in mouse models, identifying two mAbs that bind to CEACAM6 variants in tumors.

A simple strategy to reduce the salivary gland and kidney uptake of PSMA targeting small molecule radiopharmaceuticals

This study shows adding cold PSMA-11 reduces salivary gland and kidney uptake of [177Lu]-PSMA-617 without affecting tumor uptake in mice.

rapidPop: Rapid population assessments of wildlife using camera trap data in R Shiny Applications

The paper introduces an R package for rapid population assessments using camera trap data, enabling occupancy modeling with Shiny applications to analyze density changes.

Tunability of DNA polymerase stability during eukaryotic DNA replication

The paper shows how DNA polymerase stability and exchange dynamics in the yeast replisome are tuned by local concentrations, enabling efficient replication and adaptation to genomic challenges.

Targeted brain tumor radiotherapy using an Auger emitter

A PARP1-targeted Auger radiotherapeutic shows translational potential for imaging and killing cancer cells, resulting in tumor delineation and prolonged survival in a glioblastoma model.

Recycling of single-stranded DNA-binding protein by the bacterial replisome.

This study visualizes how the E. coli replisome recruits and recycles single-stranded DNA-binding protein using two mechanisms, showing their physiological relevance.

A Primase-Induced Conformational Switch Controls the Stability of the Bacterial Replisome

This study identifies a primase-induced conformational switch that enhances the stability of the bacterial replisome by strengthening the interaction between the polymerase holoenzyme and the replicative helicase.

Nuclease dead Cas9 is a programmable roadblock for DNA replication

The paper uses a modified Cas9 protein to create a programmable roadblock for studying DNA replication fork arrest in vitro and in vivo.

Spatial and temporal organization of RecA in the Escherichia coli DNA-damage response

This study uses a fluorescent probe to track RecA dynamics in live E. coli, showing it is stored during normal metabolism and rapidly mobilizes to form SOS-signaling complexes upon DNA damage.

Machine learning to classify animal species in camera trap images: applications in ecology

This paper trains a machine learning model to classify animal species in camera trap images, achieving high accuracy and providing an R package for ecological use.