Author

M. E. Peter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 7 Cell Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 8 Research Focus:differential expression· 4 Research Focus:gene regulatory network inference· 4 Research Focus:host-pathogen & immune response· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3

Frequent Co-Authors

E. T. Bartom· 7 shared A. E. Murmann· 6 shared M. Patel· 4 shared Q. Q. Gao· 4 shared A. A. Sarshad· 3 shared A. Haluck-Kangas· 3 shared M. Hafner· 3 shared S. Chen· 3 shared

Activity by Year

2017-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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7 shared papersCell Biology

E. T. Bartom

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Author profile →

11 papers

Recent·Most cited

CD95/Fas ligand mRNA is toxic to cells through more than one mechanism

A. Haluck-Kangas, M. Fink, E. T. Bartom, M. E. Peter

This study shows CD95L mRNA induces toxicity through multiple mechanisms, including DISE and Ago-dependent RNAi, with varying dependence on Ago proteins across cell lines.

bioRxiv · Oct 3, 2022Cell Biology

Contribution of 6mer seed toxicity to HIV-1 induced cytopathicity

A. Vaidyanathan, H. E. Taylor, T. J. Hope, R. T. D'Aquila, E. T. Bartom, J. F. Hultquist, M. E. Peter

This paper identifies HIV-encoded miRNA HIV-miR-TAR-3p as a cytotoxic factor that induces cell death via DISE through a noncanonical 6mer seed, revealing a mechanism for HIV-induced cytopathicity.

bioRxiv · Oct 1, 2022 · PreprintMicrobiology

CD95 expression in triple negative breast cancer blocks induction of an inflammatory state through differential regulation of NF-kB Signaling

J.-P. Guegan, J. Pollet, C. Ginestier, E. Charafe-Jauffret, M. E. Peter, P. Legembre

This study identifies CD95 interaction partners KPC2 and p65, showing CD95 loss in TNBCs promotes NF-κB activation and pro-inflammatory cytokine production.

bioRxiv · Apr 7, 2021 · PreprintCancer Biology

Tumor expressed CD95 causes suppression of anti-tumor activity of NK cells in a model of triple negative breast cancer

A. S. Qadir, J. P. Guegan, C. Ginestier, A. Chaibi, A. Bessede, E. Charafe-Jauffret, M. Macario, V. Lavoue, T. de la Motte Rouge, C. Law, J. Vilker, H. Wang, E. Stroup, M. J. Schipma, B. Bridgeman, , M. E. Peter

This study shows that CD95 expression by tumor cells suppresses NK cell anti-tumor activity in triple negative breast cancer, leading to reduced tumor growth in immune-competent mice.

bioRxiv · Feb 12, 2021Cancer Biology

The balance between toxic versus nontoxic microRNAs determines platinum sensitivity in ovarian cancer

M. Patel, Y. Wang, E. Bartom, R. Dhir, K. Nephew, D. Matei, A. Murmann, E. Lengyel, M. E. Peter

The paper shows that the ratio of toxic to nontoxic miRNAs in RISC predicts platinum sensitivity in ovarian cancer.

bioRxiv · Jan 24, 2021Cancer Biology

Identification of the toxic 6mer seed consensus in human cancer cells

M. Patel, E. T. Bartom, B. Paudel, M. Kocherginsky, K. L. O'Shea, A. E. Murmann, M. E. Peter

The paper identifies GGGGGC as the most toxic 6mer seed in human cancer cells, confirming its mechanism through targeted gene disruption and reporter assays.

bioRxiv · Dec 22, 2020Cancer Biology

6mer seed toxicity in viral microRNAs

A. E. Murmann, E. T. Bartom, M. J. Schipma, J. Vilker, S. Chen, M. E. Peter

The paper identifies 6mer seed toxicity in viral miRNAs, showing some v-miRNAs kill cells via G-rich 6mer sequences, unlike most cellular miRNAs.

bioRxiv · Nov 12, 2019Cell Biology

CD95/Fas ligand mRNA is toxic to cells

W. Putzbach, A. Haluck-Kangas, Q. Q. Gao, A. A. Sarshad, E. T. Bartom, A. M. Stults, A. S. Qadir, M. Hafner, M. E. Peter

The paper shows that full-length CD95L mRNA is toxic to cells and induces apoptosis through sRNA processing independent of Dicer and Drosha, suggesting a new role for RNAi in cell fate regulation.

bioRxiv · Sep 14, 2018Cancer Biology

6mer seed toxicity in tumor suppressive microRNAs

Q. Q. Gao, W. E. Putzbach, A. E. Murmann, S. Chen, A. A. Sarshad, J. M. Peter, E. T. Bartom, M. Hafner, M. E. Peter

The paper identifies 6mer seed sequences in miRNAs that are toxic to cancer cells, showing that tumor suppressive miRNAs use these toxic seeds to kill cancer cells.

bioRxiv · Aug 31, 2018Cell Biology

Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells

A. E. Murmann, Q. Q. Gao, W. Putzbach, M. Patel, E. T. Bartom, C. Law, B. Bridgeman, S. Chen, K. M. McMahon, C. S. Thaxton, M. E. Peter

The paper shows that siRNAs based on CAG TNRs are toxic to cancer cells and slow tumor growth in a mouse model without toxicity.

bioRxiv · Jan 12, 2018Cancer Biology

Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism

W. Putzbach, Q. Q. Gao, M. Patel, S. van Dongen, A. Haluck-Kangas, A. A. Sarshad, E. Bartom, K.-Y. A. Kim, D. M. Scholtens, M. Hafner, J. C. Zhao, A. E. Murmann, M. E. Peter

The paper shows that many si/shRNAs targeting CD95 or CD95L induce cancer cell death via an off-target mechanism called DISE by eliminating survival genes.

bioRxiv · Sep 14, 2017Cancer Biology