Author

B. Posorske

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

F. A. Karreth· 1 shared G. M. DeNicola· 1 shared K. Y. Tsai· 1 shared N. Jasani· 1 shared O. Vera· 1 shared X. Xu· 1 shared Y. Kim· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

F. A. Karreth

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1 paper

Recent·Most cited

MAPK-mediated PHGDH induction is essential for melanoma formation and represents an actionable vulnerability

N. Jasani, X. Xu, B. Posorske, Y. Kim, O. Vera, K. Y. Tsai, G. M. DeNicola, F. A. Karreth

This study identifies PHGDH induction via MAPK and mTORC1 pathways as essential for melanoma formation and shows that combining BRAFV600E inhibition with serine restriction can target this vulnerability.

bioRxiv · Apr 11, 2024 · PreprintCancer Biology