Author

O. Vera

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 4 Approach:experimental assay· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

F. A. Karreth· 4 shared X. Xu· 4 shared N. Jasani· 3 shared I. Bok· 2 shared K. Nakamura· 2 shared K. Wang· 2 shared K. Y. Tsai· 2 shared A. Angarita· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersCancer Biology

F. A. Karreth

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5 papers

Recent·Most cited

MAPK-mediated PHGDH induction is essential for melanoma formation and represents an actionable vulnerability

N. Jasani, X. Xu, B. Posorske, Y. Kim, O. Vera, K. Y. Tsai, G. M. DeNicola, F. A. Karreth

This study identifies PHGDH induction via MAPK and mTORC1 pathways as essential for melanoma formation and shows that combining BRAFV600E inhibition with serine restriction can target this vulnerability.

bioRxiv · Apr 11, 2024 · PreprintCancer Biology

Chromosome 1q amplification perturbs a ceRNA network to promote melanoma metastasis

X. Xu, K. Wang, O. Vera, A. Verma, O. Elemento, X. Yu, F. A. Karreth

The paper shows that chromosome 1q amplification promotes melanoma metastasis by overexpressing ceRNAs that sequester tumor suppressor miRNAs.

bioRxiv · Nov 14, 2021Cancer Biology

MAPK-induced miR-29 targets MAFG and suppresses melanoma development

O. Vera, I. Bok, N. Jasani, K. Nakamura, X. Xu, N. Mecozzi, A. Angarita, K. Wang, K. Y. Tsai, F. A. Karreth

This study shows that MAPK-induced miR-29 suppresses melanoma by targeting MAFG, and its inactivation accelerates tumor development.

bioRxiv · Jan 27, 2020Cancer Biology

A novel role for the tumor suppressor gene ITF2 in lung tumorigenesis and chemotherapy response

O. Pernia, A. Sastre-Perona, C. Rodriguez-Antolin, A. Garcia-Guede, M. Palomares-Bralo, R. Rosas, D. Sanchez-Cabrero, C. Rodriguez, R. Martin-Arenas, V. Pulido, J. de Castro, P. Santisteban, O. Vera, I. Ibanez de Caceres

This study identifies ITF2 as a tumor suppressor involved in cisplatin resistance and chemotherapy response in epithelial tumors, with potential as a biomarker and therapeutic target.

bioRxiv · Jan 15, 2020Cancer Biology

A versatile ES cell-based melanoma mouse modeling platform

I. Bok, O. Vera, X. Xu, N. Jasani, K. Nakamura, J. Reff, A. Nenci, J. G. Gonzalez, F. A. Karreth

This paper develops an ESC-based melanoma mouse model platform to rapidly generate genetically engineered mice for melanoma research using multiple genetic strategies.

bioRxiv · Aug 31, 2019Cancer Biology