Author

B. R. Topacio

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:proteomics· 1

Frequent Co-Authors

E. Zatulovskiy· 2 shared J. M. Skotheim· 2 shared C. S. Tambo· 1 shared D. F. Berenson· 1 shared J. Sage· 1 shared M. Koivomägi· 1 shared S. Cristea· 1 shared S. M. Rubin· 1 shared

Activity by Year

2018-2018 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

E. Zatulovskiy

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2 papers

Recent·Most cited

Cell BiologybioRxivNov 19, 2018

Cell growth dilutes the cell cycle inhibitor Rb to trigger cell division

E. Zatulovskiy, D. F. Berenson, B. R. Topacio, J. M. Skotheim

The paper shows that cell growth dilutes the cell cycle inhibitor Rb to drive cell division in human cells, establishing a molecular mechanism for cell size homeostasis.

DOI 10.1126/science.aaz6213

humanexperimental assay

𝕏 PostBluesky

Cell BiologybioRxivAug 21, 2018

Cyclin D-Cdk4,6 drives cell cycle progression via the retinoblastoma protein’s C-terminal helix

B. R. Topacio, E. Zatulovskiy, S. Cristea…·J. M. Skotheim

This study shows cyclin D-Cdk4,6 drives cell cycle progression by phosphorylating Rb's C-terminal helix, which is distinct from other cyclin-Cdk interactions and critical for tumor suppression.

DOI 10.1016/j.molcel.2019.03.020

humanproteomics

𝕏 PostBluesky