E. Zatulovskiy

The G1/S transition is promoted by Rb degradation via the E3 ligase UBR5

The paper identifies UBR5-mediated Rb degradation as a mechanism promoting G1/S transition by reducing Rb levels in early G1.

The cell cycle inhibitor RB is diluted in G1 and contributes to controlling cell size in the mouse liver

This study shows that RB dilution during G1 phase controls cell size in mouse liver by linking cell growth to the G1/S transition.

Increasing cell size remodels the proteome and promotes senescence

The paper shows that increasing cell size remodels the proteome and promotes senescence, but polyploidization can prevent this by altering the DNA-to-ploidy ratio.

Constitutive expression of a fluorescent protein reports the size of live human cells

This paper introduces a fluorescent protein reporter to measure live human cell size, showing it is more robust than existing methods and useful for studying size-dependent cell cycle regulation.

Cell growth dilutes the cell cycle inhibitor Rb to trigger cell division

The paper shows that cell growth dilutes the cell cycle inhibitor Rb to drive cell division in human cells, establishing a molecular mechanism for cell size homeostasis.

Cyclin D-Cdk4,6 drives cell cycle progression via the retinoblastoma protein’s C-terminal helix

This study shows cyclin D-Cdk4,6 drives cell cycle progression by phosphorylating Rb's C-terminal helix, which is distinct from other cyclin-Cdk interactions and critical for tumor suppression.