Cell BiologybioRxiv
Cyclin D-Cdk4,6 drives cell cycle progression via the retinoblastoma protein’s C-terminal helix
B. R. Topacio, E. Zatulovskiy, S. Cristea…·J. M. Skotheim
This study shows cyclin D-Cdk4,6 drives cell cycle progression by phosphorylating Rb's C-terminal helix, which is distinct from other cyclin-Cdk interactions and critical for tumor suppression.
DOI 10.1016/j.molcel.2019.03.020