Cyclin D-Cdk4,6 drives cell cycle progression via the retinoblastoma protein’s C-terminal helix
B. R. Topacio, E. Zatulovskiy, S. Cristea, S. Xie, C. S. Tambo, S. M. Rubin, J. Sage, M. Koivomägi, J. M. Skotheim
This study shows cyclin D-Cdk4,6 drives cell cycle progression by phosphorylating Rb's C-terminal helix, which is distinct from other cyclin-Cdk interactions and critical for tumor suppression.
bioRxiv · Aug 21, 2018Cell Biology