M. A. Kutuzov

Regulation of temporal cytokine production by co-stimulation receptors in TCR-T cells is lost in CAR-T cells

This study compares cytokine production kinetics in TCR-T cells and CAR-T cells with and without co-stimulation, finding that 2nd-generation CAR-T cells sustain cytokine production without co-stimulation.

Analysis of emergent bivalent antibody binding identifies the molecular reach as a critical determinant of SARS-CoV-2 neutralisation potency

This paper develops a bivalent binding model to analyze how molecular reach affects SARS-CoV-2 neutralization potency across antibodies.

Mechanical forces impair antigen discrimination by reducing differences in T cell receptor off-rates

The paper shows mechanical forces reduce T cell antigen discrimination by accelerating off-rates of higher-affinity antigens.

Effects of common mutations in the SARS-CoV-2 Spike RBD domain and its ligand the human ACE2 receptor on binding affinity and kinetics

This study analyzes how common mutations in SARS-CoV-2 Spike RBD and human ACE2 affect binding affinity and kinetics, identifying their roles in transmission and immune escape.

The discriminatory power of the T cell receptor

This study measures TCR discriminatory power against pMHC antigens and finds it is imperfect, with T cells responding to low-affinity self pMHC with KD ~1 mM.

A tissue-like platform for studying engineered quiescent human T-cells’ interactions with dendritic cells

This paper develops a tissue-like platform to study interactions between engineered quiescent human T-cells and dendritic cells, demonstrating CD4 help and PD-1 checkpoint blockade effects.

CD2 expression acts as a quantitative checkpoint for immunological synapse structure and T-cell activation.

The paper shows CD2 expression levels determine immunological synapse structure and T-cell activation by influencing CD2-CD58 localization and Src-family kinase recruitment.