Author

T. R. Weikl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Approach:comparative / phylogenetic analysis· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

B. Rozycki· 3 shared A. Huhn· 1 shared C. Roth· 1 shared J. Pettmann· 1 shared L. Awada· 1 shared L. Limozin· 1 shared M. A. Kutuzov· 1 shared M. Delbianco· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersImmunology

B. Rozycki

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4 papers

Recent·Most cited

Role of van der Waals, electrostatic, and hydrogen-bond interactions for the relative stability of cellulose Iβ and II crystals

R. Kullmann, M. Delbianco, C. Roth, T. R. Weikl

The paper compares the stability of cellulose Iβ and II crystals by analyzing electrostatic, van der Waals, and hydrogen-bond interactions using classical force fields.

bioRxiv · Mar 4, 2024Biophysics

Mechanical forces impair antigen discrimination by reducing differences in T cell receptor off-rates

J. Pettmann, L. Awada, B. Rozycki, A. Huhn, S. Faour, M. A. Kutuzov, L. Limozin, T. R. Weikl, P. A. van der Merwe, P. Robert, O. Dushek

The paper shows mechanical forces reduce T cell antigen discrimination by accelerating off-rates of higher-affinity antigens.

bioRxiv · May 5, 2022 · PreprintImmunology

Cooperative Stabilization of Close-Contact Zones Leads to Sensitivity and Selectivity in T-Cell Recognition

B. Rozycki, T. R. Weikl

The paper demonstrates that cooperative stabilization of close-contact zones in T-cell adhesion is sensitive to 1-3 foreign-peptide-MHC complexes and occurs at a sharp affinity threshold, implying selectivity in T-cell recognition.

bioRxiv · Mar 2, 2021Immunology

Structural variability and concerted motions of the T cell receptor - CD3 complex

P. R. Pandey, B. Rozycki, R. Lipowsky, T. R. Weikl

This study uses molecular dynamics simulations to analyze structural variability and motions of the TCR-CD3 complex, revealing tilt angles and coupled domain movements.

bioRxiv · Feb 3, 2021Immunology