M. A. Mall

Ileal mucus viscoelastic properties differ in Crohns disease

This study examines ileal mucus viscoelastic properties in Crohn's disease patients and controls, finding significant differences in viscoelasticity and mesh size.

A Cell-Permeable Nanobody to Restore F508del Cystic Fibrosis Transmembrane Conductance Regulator Activity

This paper develops a cell-permeable nanobody to restore function of the misfolded F508del-CFTR protein in CF bronchial epithelial cells.

Reflection confocal microscopy for quantitative assessment of airway surface liquid dysregulation and pharmacological rescue in cystic fibrosis under near-physiological conditions

This paper introduces confocal reflection microscopy as a method to measure airway surface liquid height in cystic fibrosis models without perturbing the ASL, showing it is sensitive to detect ASL changes and therapeutic responses.

Comprehensive characterization of the viscoelastic properties of Bovine Submaxillary Mucin (BSM) hydrogels and the effect of additives

This study characterizes the viscoelastic properties of Bovine Submaxillary Mucin (BSM) hydrogels and examines the effects of additives on their rheological behavior.

Increased pulmonary monocyte infiltration and attenuated phagocytosis defines perinatal dysfunction of innate immunity in Cystic Fibrosis

The paper identifies increased monocyte infiltration and reduced phagocytosis in CF lungs at birth, suggesting innate immune dysfunction and the need for early treatment.

Longitudinal Micro-Computed Tomography Detects Onset and Progression of Pulmonary Fibrosis in Conditional Nedd4-2 Deficient Mice

This study uses longitudinal micro-CT to detect and quantify the onset and progression of IPF-like lung disease in Nedd4-2-/- mice.

Enhanced Airway Epithelial Response to SARS-CoV-2 Infection in Children is Critically Tuned by the Cross-Talk Between Immune and Epithelial Cells

This study identifies enhanced cytokine-mediated cross-talk between immune and epithelial cells in children as a mechanism for their improved antiviral response to SARS-CoV-2.

Tamoxifen reduces inflammatory infiltration of neutrophils in the airways.

This study shows tamoxifen reduces neutrophil infiltration in inflamed airways across multiple mouse models without affecting mucociliary clearance.

Lack of Kcnn4 improves mucociliary clearance in muco-obstructive lung disease.

This study shows that inhibiting KCa3.1 improves mucociliary clearance in a mouse model of muco-obstructive lung disease.

Antigen-driven PD1+Tox+Eomes+ and PD1+Tox+BHLHE40+ synovial T lymphocytes regulate chronic inflammation in situ

The paper identifies distinct subpopulations of synovial T lymphocytes in JIA patients using single-cell RNA-sequencing and shows their roles in regulating chronic inflammation.