Author

B. Van Houten

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Assay:fluorescence / live-cell microscopy· 2 Research Focus:cell type annotation· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

B. D. Freudenthal· 2 shared M. A. Schaich· 2 shared M. Schaich· 2 shared T. M. Weaver· 2 shared V. Roginskaya· 2 shared A. Afek· 1 shared A. C. Drohat· 1 shared A. Hoda· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

B. D. Freudenthal

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA.

S. R. Hengel, K. Oppenheimer, C. Smith, M. Schaich, H. L. Rein, J. Martino, K. Darrah, O. C. Ezekwenna, K. R. Burton, B. Van Houten, M. Spies, K. A. Bernstein

This study shows the Shu complex enhances RAD51 activity by stabilizing filaments and promoting RPA diffusion on ssDNA, with implications for cancer therapy.

bioRxiv · Feb 14, 2024Biochemistry

Single-molecule analysis of purified proteins and nuclear extracts: insights from 8-oxoguanine glycosylase 1

M. Schaich, T. M. Weaver, V. Roginskaya, B. D. Freudenthal, B. Van Houten

This study compares single-molecule DNA binding dynamics of purified OGG1 and nuclear extracts using SMADNE, revealing differences in undamaged DNA binding and increased binding lifetime for a catalytically dead variant in nuclear extracts.

bioRxiv · Nov 1, 2023Biochemistry

Single-molecule analysis reveals TDG exhibits multiple modes of linear diffusion to process 5-formylcytosine.

B. L. Schnable, M. A. Schaich, V. Roginskaya, L. P. Leary, T. M. Weaver, B. D. Freudenthal, A. C. Drohat, B. Van Houten

This study uses single-molecule fluorescence to show TDG uses multiple diffusion modes to search for DNA lesions and how its structure affects nucleosome interactions.

bioRxiv · Oct 4, 2023Biophysics

UV irradiation remodels the specificity landscape of transcription factors

Z. Mielko, Y. Zhang, Y. Liu, M. A. Schaich, B. Schnable, D. Burdinski, S. Adar, M. Pufall, B. Van Houten, R. Gordan, A. Afek

This study investigates how UV irradiation affects transcription factor DNA-binding specificity using UV-Bind, finding reduced specificity and unexpected increased binding at non-consensus sites.

bioRxiv · Oct 7, 2022Biophysics

DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer

M. Zhivagui, A. Hoda, N. Valenzuela, Y.-Y. Yeh, J. Dai, Y. He, S. Nandi, B. Otlu, B. Van Houten, L. B. Alexandrov

This study shows UV-nail polish dryer radiation causes DNA damage and somatic mutations in mammalian cells, with mutagenic patterns linked to reactive oxygen species.

bioRxiv · Feb 3, 2021Cancer Biology