Mutation of influenza A virus PA-X decreases pathogenicity in chicken embryos and can increase the yield of reassortant candidate vaccine viruses
S. Hussain, M. L. Turnbull, H. M. Wise, B. W. Jagger, P. M. Beard, K. Kovacikova, J. K. Taubenberger, L. Vervelde, O. G. Engelhardt, P. Digard
This paper shows that mutating the PA-X gene in influenza A virus reduces pathogenicity in chicken embryos and increases HA yield in vaccine reassortant viruses.
bioRxiv · Sep 6, 2018Microbiology