Author

M. L. Turnbull

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:variant calling· 2 Organism:chicken / avian· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. Palmarini· 3 shared P. Digard· 3 shared R. M. Pinto· 3 shared S. J. Wilson· 3 shared A. Wickenhagen· 2 shared J. Hughes· 2 shared M. Varela· 2 shared O. G. Engelhardt· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersMicrobiology

M. Palmarini

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Author profile →

5 papers

Recent·Most cited

Zoonotic avian influenza viruses evade human BTN3A3 restriction

R. M. Pinto, S. Bakshi, S. Lytras, M. K. Zakaria, S. Swingler, J. C. Worrell, V. Herder, M. Varjak, N. Cameron-Ruiz, M. Collados-Rodriguez, M. Varela, A. Wickenhagen, C. Loney, Y. Pei, J. Hughes, , M. Palmarini

This study identifies BTN3A3 as a human restriction factor that inhibits avian influenza viruses but not human IAVs, with resistance linked to specific NP mutations.

bioRxiv · Jun 14, 2022 · PreprintMicrobiology

In vitro evolution of Remdesivir resistance reveals genome plasticity of SARS-CoV-2

A. M. Szemiel, A. Merits, R. J. Orton, O. MacLean, A. Wickenhagen, G. Lieber, R. M. Pinto, M. L. Turnbull, S. Wang, D. Mair, A. da Silva Filipe, B. J. Willett, S. J. Wilson, A. H. Patel, E. C. Thomson, , M. E. Stewart

This study shows that in vitro evolution of SARS-CoV-2 under remdesivir selects for resistant mutations, but these mutations do not spread widely in global variants.

bioRxiv · Feb 1, 2021Microbiology

TRIM69 inhibits Vesicular Stomatitis Indiana Virus (VSIV)

S. J. Rihn, M. A. Aziz, D. G. Stewart, J. Hughes, M. L. Turnbull, M. Varela, E. Sugrue, C. S. Herd, M. Stanifer, S. P. Sinkins, M. Palmarini, S. J. Wilson

This study identifies TRIM69 as an interferon-induced gene that potently inhibits VSIV, with specific antiviral activity and evolutionary signatures of positive selection.

bioRxiv · Jun 13, 2019Microbiology

Segment 2 from influenza A(H1N1)pdm09 viruses confers temperature sensitive HA yield on candidate vaccine virus growth in eggs that is complemented by PB2 701D

S. Hussain, M. L. Turnbull, R. M. Pinto, J. W. McCauley, O. G. Engelhardt, P. Digard

This study shows that pdm09 segment 2 in candidate vaccine viruses reduces HA yield in eggs at 37.5°C but this temperature sensitivity is compensated by the PB2 701D mutation, improving HA yield.

bioRxiv · Feb 8, 2019Microbiology

Mutation of influenza A virus PA-X decreases pathogenicity in chicken embryos and can increase the yield of reassortant candidate vaccine viruses

S. Hussain, M. L. Turnbull, H. M. Wise, B. W. Jagger, P. M. Beard, K. Kovacikova, J. K. Taubenberger, L. Vervelde, O. G. Engelhardt, P. Digard

This paper shows that mutating the PA-X gene in influenza A virus reduces pathogenicity in chicken embryos and increases HA yield in vaccine reassortant viruses.

bioRxiv · Sep 6, 2018Microbiology