Author

O. G. Engelhardt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Organism:chicken / avian· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

M. L. Turnbull· 2 shared P. Digard· 2 shared S. Hussain· 2 shared A. Huckriede· 1 shared B. W. Jagger· 1 shared C. A.M. de Haan· 1 shared D. J. Kelvin· 1 shared F. Sicca· 1 shared

Activity by Year

2018-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMicrobiology

M. L. Turnbull

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3 papers

Recent·Most cited

Segment 2 from influenza A(H1N1)pdm09 viruses confers temperature sensitive HA yield on candidate vaccine virus growth in eggs that is complemented by PB2 701D

S. Hussain, M. L. Turnbull, R. M. Pinto, J. W. McCauley, O. G. Engelhardt, P. Digard

This study shows that pdm09 segment 2 in candidate vaccine viruses reduces HA yield in eggs at 37.5°C but this temperature sensitivity is compensated by the PB2 701D mutation, improving HA yield.

bioRxiv · Feb 8, 2019Microbiology

Mutation of influenza A virus PA-X decreases pathogenicity in chicken embryos and can increase the yield of reassortant candidate vaccine viruses

S. Hussain, M. L. Turnbull, H. M. Wise, B. W. Jagger, P. M. Beard, K. Kovacikova, J. K. Taubenberger, L. Vervelde, O. G. Engelhardt, P. Digard

This paper shows that mutating the PA-X gene in influenza A virus reduces pathogenicity in chicken embryos and increases HA yield in vaccine reassortant viruses.

bioRxiv · Sep 6, 2018Microbiology

Cross-protective immune responses induced by sequential influenza virus infection and by sequential vaccination with inactivated influenza vaccines

W. Dong, Y. Bhide, F. Sicca, T. Meijerhof, K. Guilfoyle, O. G. Engelhardt, L. Boon, C. A.M. de Haan, G. Carnell, N. Temperton, J. de Vries-Idema, D. J. Kelvin, A. Huckriede

This study shows that sequential vaccination with inactivated influenza vaccines can reduce pandemic virus infection severity, while subunit vaccines cannot, through cross-reactive antibodies and CD8+ T cells.

bioRxiv · May 31, 2018Microbiology