Author

B. Wielockx

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:gene regulatory network inference· 2 Assay:metabolomics· 2 Approach:statistical model· 2

Frequent Co-Authors

T. Chavakis· 5 shared A. Sinha· 3 shared A. Dahl· 2 shared A. Gerbaulet· 2 shared A. Krueger· 2 shared A. Palladini· 2 shared A. Witt· 2 shared H. Abdelmegeed· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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5 shared papersCell Biology

T. Chavakis

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

CD38 promotes hematopoietic stem cell dormancy via c-Fos

L. Ibneeva, S. P. Singh, A. Sinha, S. E. Eski, R. Wehner, L. Rupp, J. A. Perez-Valencia, A. Gerbaulet, S. Reinhardt, M. Wobus, M. Bonin, J. Sancho, F. E. Lund, A. Dahl, M. Schmitz, , T. Grinenko

This study identifies CD38 as a marker for dormant hematopoietic stem cells and shows it promotes dormancy through the cADPR/Ca2+/c-Fos/p57Kip2 pathway.

bioRxiv · Feb 8, 2023 · PreprintCell Biology

Succinate mediates inflammation-induced adrenocortical dysfunction

I. Mateska, A. Witt, E. Hagag, A. Sinha, C. Yilmaz, E. Thanou, N. Sun, O. Kolliniati, M. Patschin, H. Abdelmegeed, H. Henneicke, W. Kanczkowski, B. Wielockx, C. Tsatsanis, A. Dahl, , V. I. Alexaki

This study identifies the IL-1β-DNMT1-SDHB-succinate axis as a mechanism by which inflammation impairs adrenal steroidogenesis.

bioRxiv · Apr 29, 2022Immunology

The distinct role of ALDH1A1 and ALDH1A3 in the regulation of prostate cancer metastases

I. Gorodetska, A. Offermann, J. Pueschel, V. Lukiyanchuk, D. Gaete, A. Kurzyukova, V. Labitzky, F. Schwarz, T. Lange, F. Knopf, B. Wielockx, M. Krause, S. Perner, A. Dubrovska

This study identifies ALDH1A1 and ALDH1A3 as regulators of prostate cancer metastasis and radiosensitivity, with opposing roles in predicting recurrence and metastatic burden.

bioRxiv · May 8, 2021 · PreprintCancer Biology

Obesity-associated lipidomic remodeling of the adrenal gland indicates an important role of the FADS2-arachidonic acid axis in adrenocortical hormone production

A. Witt, P. Mirtschink, A. Palladini, I. Mateska, H. Abdelmegeed, M. Grzybek, B. Wielockx, M. Peitzsch, U. Coskun, T. Chavakis, V. I. Alexaki

This study identifies obesity-induced lipidomic changes in the adrenal gland, showing that the FADS2-arachidonic acid pathway regulates adrenocortical hormone production.

bioRxiv · Sep 4, 2020 · PreprintCell Biology

HIF2α is a Direct Regulator of Neutrophil Motility

S. Sormendi, M. Deygas, A. Sinha, A. Krueger, I. Kourtzelis, G. Le Lay, M. Bernard, P. Saez, M. Gerlach, K. Franke, A. Meneses, M. Kraeter, A. Palladini, J. Guck, U. Coskun, , B. Wielockx

This study identifies HIF2α as a regulator of neutrophil motility through the PHD2-HIF2-RhoA axis, enhancing migration in hypoxic environments during inflammation.

bioRxiv · Jun 5, 2020Immunology

Hematopoietic stem cells differentiate into restricted myeloid progenitors before cell division

T. Grinenko, A. Eugster, L. Thielecke, B. Ramasz, A. Krueger, S. Dietz, I. Glauche, A. Gerbaulet, M. von Bonin, O. Basak, H. Clevers, T. Chavakis, B. Wielockx

This study shows hematopoietic stem cells can differentiate into restricted progenitors without dividing or entering the S phase, indicating fate decisions are uncoupled from cell division.

bioRxiv · Jan 30, 2018Cell Biology