S. P. Singh

Starvation resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity

The paper identifies FATP2 as a conserved target for preventing starvation-induced liver atrophy by reducing fatty acid uptake in cavefish and other species.

TGM6, a helminth secretory product, mimics TGF-β binding to TβRII to antagonize TGF-β signaling in fibroblasts

This paper shows TGM6, a helminth protein, mimics TGF-β binding to TβRII to inhibit TGF-β signaling in fibroblasts but not T cells.

Protein tyrosine phosphatase receptor kappa regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity

This study identifies PTPRK's role in promoting hepatocyte metabolic reprogramming in obesity by regulating glycolysis and lipogenesis, with potential therapeutic implications for obesity-related liver diseases.

Fluorescent Sensors for Imaging Interstitial Calcium

This paper introduces GreenT-ECs, genetically encoded calcium sensors designed for high spatio-temporal resolution imaging of interstitial calcium in live tissues.

CD38 promotes hematopoietic stem cell dormancy via c-Fos

This study identifies CD38 as a marker for dormant hematopoietic stem cells and shows it promotes dormancy through the cADPR/Ca2+/c-Fos/p57Kip2 pathway.

Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cells

This study identifies that chemokine receptors on pathogenic human T cells have mutually exclusive roles in extravasation, with CCR6 mediating arrest and CCR2 enabling transendothelial migration through distinct ligand interactions.

Human CCR6+ Th cells show both an extended stable gradient of Th17 activity and imprinted plasticity

The paper identifies an extended gradient of Th17 activity in human CCR6+ Th cells, showing both stable phenotypes and plasticity under different activation conditions.

The GxcM-Fbp17/RacC-WASP signaling cascade regulates polarized cortex assembly in migrating cells

This study identifies a signaling cascade involving GxcM, Fbp17, RacC, and WASP that regulates rear cortical actin assembly in migrating Dictyostelium cells.

Extracellular signalling modulates Scar/WAVE complex activity through Abi phosphorylation

This study shows that extracellular signals modulate Scar/WAVE complex activity through Abi phosphorylation, affecting pseudopodia dynamics and cell migration.

Lung Bronchial Epithelial Cells are HIV Targets for Proviral Genomic Integration

This study shows HIV infects and integrates into lung bronchial epithelial cells, establishing latency and contributing to obstructive lung diseases in HIV-positive individuals.

Differential modulation of heat inducible genes across diverse genotypes and molecular cloning of a sHSP from Pearl millet

The paper profiles heat shock gene transcripts in Pearl millet genotypes under heat stress and clones a sHSP gene from a thermotolerant line, showing transcript expression as a useful screening tool for heat tolerance.

Consensus mutagenesis and ancestral reconstruction provide insight into the substrate specificity and evolution of the front-end Δ6-desaturase family

This study uses consensus mutagenesis and ancestral reconstruction to analyze the substrate specificity and evolutionary adaptation of Δ6-desaturases in marine algae.

Biochemical, serological and molecular confirmation of Salmonella isolates

The paper confirms 94 Salmonella isolates as S. Typhimurium using morphological, biochemical, serological, and molecular methods.