Author

B. Z. Zhang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

K. J. Simpson· 2 shared K. M. Fujihara· 2 shared N. J. Clemons· 2 shared S. Haupt· 2 shared W. A. Phillips· 2 shared B. Nijagal· 1 shared C. S. Cabalag· 1 shared C.-S. M. Ang· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

K. J. Simpson

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2 papers

Recent·Most cited

Genome-wide CRISPR screens reveal APR-246 (Eprenetapopt) triggers ferroptosis and inhibits iron-sulfur cluster biogenesis

K. M. Fujihara, B. Z. Zhang, T. D. Jackson, B. Nijagal, C.-S. M. Ang, I. Nikolic, V. Sutton, J. Trapani, K. J. Simpson, D. Stojanovski, S. Leimkuehler, S. Haupt, W. A. Phillips, N. J. Clemons

This paper identifies APR-246's mechanism of inducing ferroptosis and inhibiting iron-sulfur cluster biogenesis through cysteine conjugation in mutant-p53 cancer cells.

bioRxiv · Nov 29, 2020 · PreprintCancer Biology

SLC7A11 is a superior determinant of APR-246 (Eprenetapopt) response than TP53 mutation status

K. M. Fujihara, M. Corrales-Benitez, C. S. Cabalag, B. Z. Zhang, H. S. Ko, D. S. Liu, K. J. Simpson, Y. Haupt, S. Haupt, W. A. Phillips, N. J. Clemons

This study identifies SLC7A11 expression as a better predictor of response to APR-246 than TP53 mutation status using cell line data and functional validation.

bioRxiv · Nov 29, 2020Cancer Biology