K. J. Simpson

Multimodal decoding of human liver regeneration

This study uses single-nuclei RNA sequencing and spatial profiling to create a single-cell atlas of human liver regeneration, identifying a novel migratory hepatocyte subpopulation and demonstrating that wound closure precedes hepatocyte proliferation.

RNA decay defines the therapeutic response to transcriptional perturbation in leukaemia

The paper shows that mRNA decay rates determine the effectiveness of transcriptional inhibitors in leukemia, with short-lived mRNAs being more responsive and long-lived ones being modulated by RNA-binding proteins.

Nuclear stabilisation of p53 requires a functional nucleolar surveillance pathway

This study identifies the nucleolar surveillance pathway (NSP) as a central regulator of p53 stability, showing its role in integrating various cellular stresses and its potential as a therapeutic target in cancer.

Genome-wide CRISPR screens reveal APR-246 (Eprenetapopt) triggers ferroptosis and inhibits iron-sulfur cluster biogenesis

This paper identifies APR-246's mechanism of inducing ferroptosis and inhibiting iron-sulfur cluster biogenesis through cysteine conjugation in mutant-p53 cancer cells.

SLC7A11 is a superior determinant of APR-246 (Eprenetapopt) response than TP53 mutation status

This study identifies SLC7A11 expression as a better predictor of response to APR-246 than TP53 mutation status using cell line data and functional validation.

Targeting RNA Polymerase I transcription synergises with TOP1 inhibition in potentiating the DNA damage response in high-grade serous ovarian cancer

This study identifies that combining RNA Polymerase I inhibitor CX-5461 with TOP1 inhibitor topotecan enhances DNA damage response and efficacy in high-grade serous ovarian cancer.

RNA binding kinase UHMK1 regulates therapy induced metabolic adaptation in BRAFV600 melanoma

The paper identifies UHMK1 as a regulator of metabolic adaptation in BRAFV600 melanoma under targeted therapy, showing its role in mRNA transport and translation and its impact on therapy resistance.