Author

B. Nijagal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Organism:mouse· 2 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

D. P. De Souza· 2 shared A. F. Vrbanac· 1 shared A. K. Jarmusch· 1 shared A. L. Peterson· 1 shared A. Mu· 1 shared A. Sanigorski· 1 shared B. P. Howden· 1 shared B. Z. Zhang· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

D. P. De Souza

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

KatG inactivation generates vulnerabilities in isoniazid resistant strains of Mycobacterium tuberculosis

X. Wang, W. J. Jowsey, C.-Y. Cheung, N. E. Seeto, N. J. Waller, M. T. Chrisp, A. L. Peterson, B. Nijagal, P. C. Fineran, G. M. Cook, S. A. Jackson, M. B. McNeil

The paper identifies vulnerabilities in isoniazid-resistant Mycobacterium tuberculosis strains by analyzing metabolic and transcriptional changes in katG mutants.

bioRxiv · Dec 7, 2023 · PreprintMicrobiology

Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity

S. D. Martin, T. Connor, A. Sanigorski, K. A. McEwen, D. C. Henstridge, B. Nijagal, D. P. De Souza, D. Tull, P. Meikle, G. M. Kowalski, C. Bruce, P. Gregorevic, M. Febbraio, F. Collier, K. R. Walder, S. McGee

This study shows that HDAC4 and HDAC5 inhibit cell death pathways and protect muscle integrity by reducing oxidative metabolism and promoting survival under lipotoxic stress.

bioRxiv · Oct 17, 2022Cell Biology

Genome-wide CRISPR screens reveal APR-246 (Eprenetapopt) triggers ferroptosis and inhibits iron-sulfur cluster biogenesis

K. M. Fujihara, B. Z. Zhang, T. D. Jackson, B. Nijagal, C.-S. M. Ang, I. Nikolic, V. Sutton, J. Trapani, K. J. Simpson, D. Stojanovski, S. Leimkuehler, S. Haupt, W. A. Phillips, N. J. Clemons

This paper identifies APR-246's mechanism of inducing ferroptosis and inhibiting iron-sulfur cluster biogenesis through cysteine conjugation in mutant-p53 cancer cells.

bioRxiv · Nov 29, 2020 · PreprintCancer Biology

Microbe-metabolite associations linked to the rebounding murine gut microbiome post-colonization with vancomycin resistant Enterococcus faecium

A. Mu, G. P. Carter, L. Li, N. S. Isles, A. F. Vrbanac, J. T. Morton, A. K. Jarmusch, D. P. De Souza, V. K. Narayana, K. Kanojia, B. Nijagal, M. J. McConville, R. Knight, B. P. Howden, T. P. Stinear

This study investigates how the gut microbiome changes in mice after colonization with vancomycin-resistant Enterococcus faecium, identifying metabolite associations linked to bacterial shifts.

bioRxiv · May 31, 2020 · PreprintMicrobiology