Author

N. J. Clemons

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

K. M. Fujihara· 3 shared W. A. Phillips· 3 shared B. Z. Zhang· 2 shared D. Stojanovski· 2 shared K. J. Simpson· 2 shared S. Haupt· 2 shared T. D. Jackson· 2 shared A. E. Frazier· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCancer Biology

K. M. Fujihara

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Caspase-2 protects against ferroptotic cell death

S. Dawar, M. C. Benitez, Y. Lim, T. A. Dite, J. M. Yousef, N. Thio, S. Garciaz, T. D. Jackson, J. V. Milne, L. F. Dagley, W. A. Phillips, S. Kumar, N. J. Clemons

This study shows caspase-2 protects mutant-p53 cancer cells from ferroptotic death by non-proteolytically interacting with proteins to limit GPX4 degradation.

bioRxiv · Aug 22, 2023Cancer Biology

High-content profiling reveals a unified model of copper ionophore dependent cell death in oesophageal adenocarcinoma

R. E. Hughes, R. J. Elliott, X. Li, A. F. Munro, A. Makda, R. N. Carter, N. M. Morton, K. Fujihara, N. J. Clemons, R. Fitzgerald, J. R. O'Neill, T. Hupp, N. O. Carragher

This study identifies a unified mechanism of copper ionophore-induced cell death in oesophageal adenocarcinoma using high-content profiling and omic analyses.

bioRxiv · Oct 5, 2021 · PreprintCancer Biology

Genome-wide CRISPR screens reveal APR-246 (Eprenetapopt) triggers ferroptosis and inhibits iron-sulfur cluster biogenesis

K. M. Fujihara, B. Z. Zhang, T. D. Jackson, B. Nijagal, C.-S. M. Ang, I. Nikolic, V. Sutton, J. Trapani, K. J. Simpson, D. Stojanovski, S. Leimkuehler, S. Haupt, W. A. Phillips, N. J. Clemons

This paper identifies APR-246's mechanism of inducing ferroptosis and inhibiting iron-sulfur cluster biogenesis through cysteine conjugation in mutant-p53 cancer cells.

bioRxiv · Nov 29, 2020 · PreprintCancer Biology

SLC7A11 is a superior determinant of APR-246 (Eprenetapopt) response than TP53 mutation status

K. M. Fujihara, M. Corrales-Benitez, C. S. Cabalag, B. Z. Zhang, H. S. Ko, D. S. Liu, K. J. Simpson, Y. Haupt, S. Haupt, W. A. Phillips, N. J. Clemons

This study identifies SLC7A11 expression as a better predictor of response to APR-246 than TP53 mutation status using cell line data and functional validation.

bioRxiv · Nov 29, 2020Cancer Biology

Neuronal-specific function of hTim8a in Complex IV assembly provides insight into the molecular mechanism underlying Mohr-Tranebjaerg syndrome

Y. Kang, A. J. Anderson, D. P. De Souza, C. S. Palmer, K. M. Fujihara, T. Stait, A. E. Frazier, N. J. Clemons, D. Tull, D. R. Thorburn, M. J. McConville, M. T. Ryan, D. A. Stroud, D. Stojanovski

This study identifies hTim8a's role in neuronal Complex IV assembly and shows how its loss causes oxidative stress and apoptosis, contributing to Mohr-Tranebjaerg syndrome.

bioRxiv · Aug 5, 2019 · PreprintCell Biology