A TLR7/9-IFNα-LDHB axis drives vital NET release and compromises antibacterial defense.
Eden G. TenBarge, Ashley D. Wise, Morgan Lynn Hetzel, Helene A Hoover, Helia Esfandiari, Bailey E. Holder, Eva Belevska, Ellie C Mennen, Sarah R McDaniel, Nicole M Vaccaro, Courtney C. Lucca, Jonathan M. Williams, Jennifer Ferris, Tim E. Sparer, Leslie J. Crofford, , Andrew J. Monteith
The paper identifies a TLR7/9-IFNα-LDHB axis that impairs NETosis in SLE, leading to bacterial susceptibility, and shows reversal with HCQ and IFNAR blockade.
bioRxiv · Oct 7, 2025 · PreprintImmunology