ImmunologybioRxivPreprint
A TLR7/9-IFNα-LDHB axis drives vital NET release and compromises antibacterial defense.
Eden G. TenBarge, Ashley D. Wise, Morgan Lynn Hetzel…·Andrew J. Monteith
The paper identifies a TLR7/9-IFNα-LDHB axis that impairs NETosis in SLE, leading to bacterial susceptibility, and shows reversal with HCQ and IFNAR blockade.