Mycobacterial Metallophosphatase MmpE Acts as a Nucleomodulin to Regulate Host Gene Expression and Promote Intracellular Survival
Liu Chen, Baojie Duan, Qiang Jiang, Yifan Wang, Yingyu Chen, Lei Zhang, Aizhen Guo
This study identifies MmpE as a nucleomodulin in Mycobacterium tuberculosis that inhibits host inflammatory gene expression and promotes intracellular survival by targeting the VDR promoter and regulating the PI3K-Akt-mTOR pathway.
bioRxiv · Jun 24, 2025Microbiology