Author

Lei Zhang

Huazhong Agricultural UniversityORCID 0000-0002-8566-6068Unclaimed ORCID profile · follow to get notified of new preprints

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Lei Zhang18 papers · University of Minnesota

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Assay:proteomics· 1

Frequent Co-Authors

Aizhen GuoiD· 2 shared Baojie Duan· 2 shared Liu CheniD· 2 shared Qiang JiangiD· 2 shared Yingyu CheniD· 2 shared Changmin HuiD· 1 shared Lu Lu· 1 shared Pingping Chen· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersMicrobiology

Aizhen GuoORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivJun 24, 2025

Mycobacterial Metallophosphatase MmpE Acts as a Nucleomodulin to Regulate Host Gene Expression and Promote Intracellular Survival

Liu Chen, Baojie Duan, Qiang Jiang…·Aizhen Guo

This study identifies MmpE as a nucleomodulin in Mycobacterium tuberculosis that inhibits host inflammatory gene expression and promotes intracellular survival by targeting the VDR promoter and regulating the PI3K-Akt-mTOR pathway.

1 citation

MicrobiologybioRxivMay 21, 2025

A Conserved Mycobacterial Nucleomodulin Hijacks the Host COMPASS Complex to Reprogram Pro-Inflammatory Transcription and Promote Intracellular Survival

Liu Chen, Baojie Duan, Pingping Chen…·Aizhen Guo

This study identifies MgdE, a mycobacterial nucleomodulin, as a protein that targets the host COMPASS complex to suppress pro-inflammatory gene transcription and enhance bacterial survival.

2 citations