A Conserved Mycobacterial Nucleomodulin Hijacks the Host COMPASS Complex to Reprogram Pro-Inflammatory Transcription and Promote Intracellular Survival
Liu Chen, Baojie Duan, Pingping Chen, Qiang Jiang, Yifan Wang, Lu Lu, Yingyu Chen, Changmin Hu, Lei Zhang, Aizhen Guo
This study identifies MgdE, a mycobacterial nucleomodulin, as a protein that targets the host COMPASS complex to suppress pro-inflammatory gene transcription and enhance bacterial survival.
bioRxiv · May 21, 2025Microbiology