Author

Barbara Nicklas

Wake Forest University Health Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Organism:human· 1 Assay:long-read sequencing· 1 Approach:matrix factorization· 1

Frequent Co-Authors

Arushi VarshneyiD· 2 shared Eric B. FaumaniD· 2 shared Evanthia E. PashosiD· 2 shared Federico Damilano· 2 shared Mary E. PiperiD· 2 shared Maya BoseiD· 2 shared Nandini ManickamiD· 2 shared Peter OrchardiD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Arushi VarshneyORCID

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2 papers

Recent·Most cited

Single-nucleus multi-omics reveals reversible molecular signatures in skeletal muscle of patients with heart failure with preserved ejection fraction

Maya Bose, Arushi Varshney, Nicholas J. Carruthers, Peter Orchard, Mary E. Piper, Evanthia E. Pashos, Vladislav Dolgachev, Nandini Manickam, Erika Curka, Pierre M. Jean Beltran, Dalane W. Kitzman, Eric B. Fauman, Federico Damilano, Rachel J. Roth Flach, Barbara Nicklas, , Stephen C.J. Parker

The paper uses single-nucleus multi-omics to study skeletal muscle changes in HFpEF patients and shows some molecular changes are reversible with lifestyle interventions.

bioRxiv · Oct 9, 2026 · PreprintGenomics

Genetic demultiplexing and transcript start site identification from nanopore sequencing of 10x Genomics multiome libraries

Joseph Mears, Peter Orchard, Arushi Varshney, Maya Bose, Catherine C. Robertson, Mary E. Piper, Evanthia E. Pashos, Vladislav A. Dolgachev, Nandini Manickam, Pierre Jean, Dalane W Kitzman, Eric B. Fauman, Federico Damilano, Rachel J. Roth Flach, Barbara Nicklas, Stephen C.J. Parker

This study demonstrates nanopore sequencing of 10x Genomics multiome libraries to capture full-length transcripts and identify TSS, showing concordance with short-read methods despite higher error rates.

bioRxiv · Apr 8, 2026 · PreprintBioinformatics