Rachel J. Roth Flach

The paper uses single-nucleus multi-omics to study skeletal muscle changes in HFpEF patients and shows some molecular changes are reversible with lifestyle interventions.

This study demonstrates nanopore sequencing of 10x Genomics multiome libraries to capture full-length transcripts and identify TSS, showing concordance with short-read methods despite higher error rates.

This study identifies CD300LG as a receptor for triglyceride-rich lipoproteins, showing its role in postprandial lipid clearance and linking it to cardiovascular disease risk.

This paper develops a two-hit mouse model of HFpEF combining diet-induced obesity and renin-mediated hypertension, showing key features of the disease and response to therapy.