Single-nucleus multi-omics reveals reversible molecular signatures in skeletal muscle of patients with heart failure with preserved ejection fraction
Maya Bose, Arushi Varshney, Nicholas J. Carruthers, Peter Orchard, Mary E. Piper, Evanthia E. Pashos, Vladislav Dolgachev, Nandini Manickam, Erika Curka, Pierre M. Jean Beltran, Dalane W. Kitzman, Eric B. Fauman, Federico Damilano, Rachel J. Roth Flach, Barbara Nicklas, , Stephen C.J. Parker
The paper uses single-nucleus multi-omics to study skeletal muscle changes in HFpEF patients and shows some molecular changes are reversible with lifestyle interventions.
bioRxiv · Oct 9, 2026 · PreprintGenomics