Barbara P. Niederöst

Mechanical overload activates hypoxia-inducible factor 1-alpha (HIF1a) in tenocytes to drive tendinopathy independently of VEGFA-mediated vascular ingrowth, and tenocyte Hif1a deletion prevents overload-induced tendon degeneration in mice.

This study shows that ECM maturation and cytoskeletal tension determine the strain threshold for stretch-induced calcium signaling in human tendon cells.

This study shows that tendon tissue response to mechanical unloading depends on the simulated physiological niche, with oxidative stress driving proteolytic matrix breakdown.