Author

Patrick Klaus Jaeger

University of ZurichORCID 0009-0003-7462-5097Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:imaging· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Barbara P. Niederöst· 2 shared Fabian S. PassiniiD· 2 shared Jess Gerrit SnedekeriD· 2 shared Maja Bollhalder· 2 shared Sandro F. FucenteseiD· 2 shared Amro A. HussieniD· 1 shared Archana G. MohananiD· 1 shared Bart GhesquièreiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Barbara P. Niederöst

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2 papers

Recent·Most cited

Cell BiologyScience Translational MedicinePeer-reviewedJan 7, 2026

✦ In-depth digest

HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment

Greta Moschini, Archana G. Mohanan, Izabella S. Niewczas…·Jess Gerrit Snedeker

Mechanical overload activates hypoxia-inducible factor 1-alpha (HIF1a) in tenocytes to drive tendinopathy independently of VEGFA-mediated vascular ingrowth, and tenocyte Hif1a deletion prevents overload-induced tendon degeneration in mice.

12 citationstop 1%

humanmouse

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BioengineeringbioRxivPreprintApr 10, 2025

Matrix maturation and cytoskeletal tension define strain thresholds for stretch-induced calcium signaling in human tendon cells

Patrick Klaus Jaeger, Fabian S. Passini, Barbara P. Niederöst…·Jess Gerrit Snedeker

This study shows that ECM maturation and cytoskeletal tension determine the strain threshold for stretch-induced calcium signaling in human tendon cells.

1 citation

humanimaging

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