Author

Ulrich Blache

University of ZurichORCID 0000-0003-4233-2268Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Barbara P. Niederöst· 2 shared Fabian S. PassiniiD· 2 shared Jess Gerrit SnedekeriD· 2 shared Stefania L. WunderliiD· 2 shared Agnese Beretta-Piccoli· 1 shared Amro A. HussieniD· 1 shared Archana G. MohananiD· 1 shared Bart GhesquièreiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

Barbara P. Niederöst

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2 papers

Recent·Most cited

Cell BiologyScience Translational MedicinePeer-reviewedJan 7, 2026

✦ In-depth digest

HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment

Greta Moschini, Archana G. Mohanan, Izabella S. Niewczas…·Jess Gerrit Snedeker

Mechanical overload activates hypoxia-inducible factor 1-alpha (HIF1a) in tenocytes to drive tendinopathy independently of VEGFA-mediated vascular ingrowth, and tenocyte Hif1a deletion prevents overload-induced tendon degeneration in mice.

12 citationstop 1%

humanmouse

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Molecular BiologyMatrix BiologyPeer-reviewedJan 7, 2020

Tendon response to matrix unloading is determined by the patho-physiological niche

Stefania L. Wunderli, Ulrich Blache, Agnese Beretta-Piccoli…·Jess Gerrit Snedeker

This study shows that tendon tissue response to mechanical unloading depends on the simulated physiological niche, with oxidative stress driving proteolytic matrix breakdown.

60 citationstop 1%

bulk RNA-seqstatistical model

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