Jess Gerrit Snedeker

Mechanical overload activates hypoxia-inducible factor 1-alpha (HIF1a) in tenocytes to drive tendinopathy independently of VEGFA-mediated vascular ingrowth, and tenocyte Hif1a deletion prevents overload-induced tendon degeneration in mice.

This paper develops a biofabrication method to create mini-tendons with tunable matrix stiffness and microchannel dimensions, showing that mechanical confinement influences nuclear morphology and cell alignment.

This study shows that ECM maturation and cytoskeletal tension determine the strain threshold for stretch-induced calcium signaling in human tendon cells.

This study identifies Adgrg6 as essential for maintaining spine alignment by regulating biomechanical properties and gene expression in connective tissues, offering therapeutic insights for adolescent idiopathic scoliosis.

This study shows that tendon tissue response to mechanical unloading depends on the simulated physiological niche, with oxidative stress driving proteolytic matrix breakdown.