Author

Zhen Wang

St. Jude Children's Research HospitalORCID 0000-0002-2725-8322Unclaimed ORCID profile · follow to get notified of new preprints

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Zhen Wang11 papers · Chinese Academy of Sciences

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Abhijit DasguptaiD· 1 shared Andrew Tang· 1 shared Barbora Vagnerova· 1 shared Boer Xie· 1 shared Chongli YuaniD· 1 shared Connor Joseph Meek· 1 shared Danting LiuiD· 1 shared David VanderwalliD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

Abhijit DasguptaORCID

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2 papers

Recent·Most cited

Alzheimer's Disease Patient Brain Extracts Induce Multiple Pathologies in Vascularized Neuroimmune Organoids for Disease Modeling and Drug Discovery

Yanru Ji, Xiaoling Chen, Zhen Wang, Connor Joseph Meek, Jenna Lillie McLean, Yang Yang, Chongli Yuan, Jean‐Christophe Rochet, Fei Liu, Ranjie Xu

This study uses vascularized neuroimmune organoids to model sporadic Alzheimer's disease and test drug efficacy.

Molecular Psychiatry · May 2, 2025Peer-reviewedNeuroscience

Human-mouse proteomics reveals the shared pathways in Alzheimer's disease and delayed protein turnover in the amyloidome

Jay M. Yarbro, Xian Han, Abhijit Dasgupta, Ka Yang, Danting Liu, Him K. Shrestha, Masihuz Zaman, Zhen Wang, Kaiwen Yu, Dong Geun Lee, David Vanderwall, Mingming Niu, Huan Sun, Boer Xie, Ping‐Chung Chen, , Junmin Peng

Alzheimer's mouse model proteomes capture 30% (amyloid-only models) to 42% (adding tau and splicing models) of consensus human AD protein changes; in 5xFAD, plaques slow degradation of plaque-associated proteins.

Nature Communications · Feb 11, 2025Peer-reviewedBiochemistry✦ In-depth digest