Kaiwen Yu

Reprogramming CAR T-Cells with designed bioPROTACs

This paper demonstrates that bioPROTACs can reprogram CAR T-cells by targeting DNMT3A, offering a tunable alternative to gene editing for enhancing T-cell function.

Cell type-resolved proteomics reveals intra- and intercellular signalingin Alzheimers disease

The paper presents a cell type-resolved proteomic atlas of Alzheimer's disease mouse models, identifying thousands of cell-specific protein changes and highlighting astrocyte-microglia signaling.

Spotiphy enables single-cell spatial whole transcriptomics across the entire section

Spotiphy transforms spatial transcriptomics data into single-cell-resolved whole-transcriptome images, revealing novel cellular compositions and spatial domains in Alzheimer's and breast tissue.

Human-mouse proteomics reveals the shared pathways in Alzheimer's disease and delayed protein turnover in the amyloidome

Alzheimer's mouse model proteomes capture 30% (amyloid-only models) to 42% (adding tau and splicing models) of consensus human AD protein changes; in 5xFAD, plaques slow degradation of plaque-associated proteins.

Human brain aging heterogeneity observed from multi-region omics data reveals a subtype closely related to Alzheimer's disease

The paper identifies an AD-like subtype in brain aging across multiple regions, showing overlap with AD gene signatures and regional differences in gene expression.