Him K. Shrestha

MakeMyFigure: An Interactive Platform for Reproducible Quantitative Data Visualization, Analysis, and Scientific Figure Construction

MakeMyFigure enables reproducible scientific figure creation by integrating data analysis, visualization, and figure assembly in a single workflow with automated documentation.

Longitudinal Proteomics Analysis of Cerebrospinal Fluid in Survivors of Childhood Acute Lymphoblastic Leukemia

The paper presents a longitudinal CSF proteomics dataset from childhood ALL survivors to study chemotherapy-induced proteomic changes and neurotoxicity mechanisms.

Cell type-resolved proteomics reveals intra- and intercellular signalingin Alzheimers disease

The paper presents a cell type-resolved proteomic atlas of Alzheimer's disease mouse models, identifying thousands of cell-specific protein changes and highlighting astrocyte-microglia signaling.

Single Plaque Proteomics Reveals the Composition and Dynamics of the Amyloid Microenvironment in Alzheimer's Disease

The paper quantifies the proteomic composition of amyloid plaques in AD models and human brains, revealing stage-dependent remodeling and conserved proteins across species.

Human-mouse proteomics reveals the shared pathways in Alzheimer's disease and delayed protein turnover in the amyloidome

Alzheimer's mouse model proteomes capture 30% (amyloid-only models) to 42% (adding tau and splicing models) of consensus human AD protein changes; in 5xFAD, plaques slow degradation of plaque-associated proteins.

A Lysate Proteome Engineering Strategy for Enhancing Cell-Free Metabolite Production

This paper describes a method to enhance cell-free metabolite production by engineering crude lysates using MAGE to selectively remove proteins, resulting in increased pyruvate production.