Depleting trafficking regulator CASK promotes intercalated disc organization and ventricular function
Camille Blandin, Gilles Dilanian, Vincent Fontaine, Nathalie Mougenot, Basile Gravez, Pierre Bobin, Laëtitia Duboscq-Bidot, Dounia Farhi, Solenne Chardonnet, Sophie Nadaud, Jose L. Sanchez-Alonzo, Andriy Shevchuk, Julia Gorelik, Estelle Gandjbakhch, Stéphane N. Hatem, , Elise Balse
This study shows that CASK depletion improves intercalated disc organization and ventricular function in multiple models, suggesting CASK as a repressor of ID structure and function in cardiac disease.
bioRxiv · Oct 14, 2024 · PreprintPhysiology