Systematic profiling of the acetyl lysine machinery reveals a role for MAPKAPK2 in bromodomain inhibitor resistance
Pata-Eting Kougnassoukou Tchara, Jérémy Loehr, Lucas Germain, Zachary Steinhart, Beatriz Gonzalez-Badillo, Anahita Lashgari, François J.-M. Chartier, Monika Tucholska, S. Picaud, James D.R. Knight, Stéphane Angers, Nicolas Bisson, Colin R. Goding, Étienne Audet‐Walsh, P. Filippakopoulos, , Jean‐Philippe Lambert
This study maps the acetyl lysine machinery interactions and identifies MAPKAPK2 as a factor contributing to resistance to BET bromodomain inhibitors in melanoma.
bioRxiv · Jul 22, 2024 · PreprintCancer Biology