P. Filippakopoulos

This study maps the acetyl lysine machinery interactions and identifies MAPKAPK2 as a factor contributing to resistance to BET bromodomain inhibitors in melanoma.

This study shows that the transcription factor MITF interacts with the MRN complex to modulate the DNA damage response in melanoma, contributing to cancer predisposition.

The paper shows BET inhibition reduces transcription but not enhancer-promoter contacts, suggesting these processes are separable.

The paper determines the crystal structure of the KLHL20-DAPK1 complex, revealing the molecular basis of DAPK1 recruitment to the KLHL20 E3 ligase and suggesting a novel target for PROTAC-based drug design.