This study maps the acetyl lysine machinery interactions and identifies MAPKAPK2 as a factor contributing to resistance to BET bromodomain inhibitors in melanoma.

bioRxiv · Jul 22, 2024 · PreprintCancer Biology

A proximity-dependent biotinylation map of a human cell: an interactive web resource

Christopher D. Go, James D.R. Knight, Archita Rajasekharan, Bhavisha Rathod, Geoffrey G. Hesketh, Kento T. Abe, Ji-Young Youn, Payman Samavarchi-Tehrani, Hui Zhang, Lucie Y. Zhu, Evelyn Popiel, Jean-Philippe Lambert, Étienne Coyaud, Sally W.T. Cheung, Dushyandi Rajendran, , Anne‐Claude Gingras

Profiling 192 subcellular markers by proximity-dependent biotinylation (BioID) in human HEK 293 cells maps 4,145 proteins across 32 compartments via 35,902 interactions, available with analysis tools at humancellmap.org.

bioRxiv · Mar 17, 2021 · PreprintMolecular Biology

A SARS-CoV-2 - host proximity interactome

Payman Samavarchi‐Tehrani, Hala S. Abdouni, James D.R. Knight, Audrey Astori, Reuben Samson, Zhen‐Yuan Lin, Dae‐Kyum Kim, Jennifer J. Knapp, Jonathan R. St‐Germain, Christopher D. Go, Brett G. Larsen, Cassandra J. Wong, Patricia Cassonnet, Caroline Demeret, Yves Jacob, , Anne‐Claude Gingras

Proximity-dependent biotinylation of 27 SARS-CoV-2 proteins in A549 cells maps 7810 virus-host proximity interactions across 2242 host proteins, including membrane-associated partners missed by affinity purification.

bioRxiv · Sep 3, 2020 · PreprintSystems Biology

Gene Information eXtension (GIX): effortless retrieval of gene product information on any website

James D.R. Knight, Payman Samavarchi‐Tehrani, Mike Tyers, Anne‐Claude Gingras

GIX retrieves gene product information effortlessly from any website without requiring user navigation or search.

Nature Methods · Jun 19, 2019Peer-reviewedBioinformatics