Iterative immunogen optimization to focus elicited responses on a conserved, subdominant influenza hemagglutinin epitope
Daniel J. Marston, Akiko Watanabe, Anyway Brenda Kapingidza, Caitlin Harris, Elizabeth S. Van Itallie, Kapil Devkota, Jayani Christopher, Peiying Liu, Beena Pun, Brianna Rhodes, McKenzie Frazier, Kaitlyn Winters, Heman Burre, Pranav Kannan, Xiaoe Liang, , Mihai L. Azoitei
The paper designs immunogens that redirect immune responses to a conserved influenza epitope using iterative machine learning and in vivo testing.
bioRxiv · Nov 4, 2025 · PreprintImmunology