Author

Alexandra Rudolph

Harvard UniversityORCID 0000-0002-4259-7816Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2

Frequent Co-Authors

Ákos NyergesiD· 2 shared Anush Chiappino-PepeiD· 2 shared George McDonald ChurchiD· 2 shared Maximilien S. Baas-ThomasiD· 2 shared Adeline Jin· 1 shared Angela TarveriD· 1 shared Bálint KintsesiD· 1 shared Behnoush Hajian· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersSynthetic Biology

Ákos NyergesORCID

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2 papers

Recent·Most cited

Synthetic genomes unveil the effects of synonymous recoding

Ákos Nyerges, Anush Chiappino-Pepe, Bogdan Budnik, Maximilien S. Baas-Thomas, Regan Flynn, Shirui Yan, Nili Ostrov, Min Liu, Meizhou Wang, Qingmei Zheng, Fangxiang Hu, Kangming Chen, Alexandra Rudolph, Xi Dawn Chen, Jenny J. Ahn, , George McDonald Church

This study uses synthetic genomes to investigate how synonymous codon recoding affects organismal fitness and develops a workflow to overcome lethal effects of codon swaps.

bioRxiv · Jun 16, 2024 · PreprintSynthetic Biology

Strategies to Identify and Edit Improvements in Synthetic Genome Segments Episomally.

Alexandra Rudolph, Ákos Nyerges, Anush Chiappino-Pepe, Matthieu Landon, Maximilien S. Baas-Thomas, George McDonald Church

The paper improves a MAGE protocol to repair mutations in synthetic genome segments, enabling successful complementation of gene deletions in Escherichia coli.

Nucleic Acids Research · Aug 16, 2023Peer-reviewedSynthetic Biology