Author

Poulomee Bose

CHU Sainte-Justine Research CenterORCID 0000-0002-8947-0118Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexey V. PshezhetskyiD· 2 shared Carlos Ramón MoralesiD· 2 shared Éric BonneiliD· 2 shared Graziella Di CristoiD· 2 shared Pierre ThibaultiD· 2 shared Xuefang PaniD· 2 shared Behzad Nasseri· 1 shared Brian BiggeriD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersGenetics

Alexey V. PshezhetskyORCID

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2 papers

Recent·Most cited

Synthetic analogue of adrenocorticotropic hormone, ACTH(4-7)PGP delays neurological manifestations in diseases of mucopolysaccharidosis III spectrum by reducing neuroinflammation and rescuing neurotransmission, synaptogenesis, and axonal demyelination

Travis Mooree, Patricia Dubot, Gustavo Monteiro Viana, Poulomee Bose, Erjun Zhang, Behzad Nasseri, Xuefang Pan, Derek N. Robertson, Lara Feulner, Mahsa Taherzadeh, Patrick Piet Van Vliet, Éric Bonneil, Shaukat Khan, Longguo Zhang, Francesco Attanasio, , Alexey V. Pshezhetsky

The paper tests a synthetic peptide ACTH(4-7)PGP in MPS III mouse models, showing it improves synaptic function, reduces neuroinflammation, and extends lifespan.

bioRxiv · Feb 24, 2026 · PreprintGenetics

Early defects in lysosomal storage diseases disrupt excitatory synaptic transmission

Camila De Britto Pará De Aragão, Luigi Bruno, Poulomee Bose, Xuefang Pan, Chanshuai Han, Peter Scottt McPherson, Erika Freemantle, Jean‐Claude Lacaille, Éric Bonneil, Pierre Thibault, Claire O’Leary, Brian Bigger, Carlos Ramón Morales, Graziella Di Cristo, Alexey V. Pshezhetsky

This study shows that lysosomal storage diseases cause synaptic structure and neurotransmission defects before cognitive symptoms appear in mice and humans.

bioRxiv · Jul 6, 2020 · PreprintNeuroscience