Non-autonomous PMK-1/p38 MAPK signaling ensures homeostatic downregulation of germline stem cell proliferation in C. elegans
Alexandre Clouet, Matthieu Valet, Benjamin Dufour, Janina Rieger, Xavier Lechasseur, Aurelia Condomat Zoumabo, Lloyd Venceslas Fotso Dzuna, Alexane Murray, Jichao Deng, Pier-Olivier Martel, Patrick Narbonne
The paper identifies a signaling pathway in C. elegans that downregulates germline stem cell proliferation in response to oocyte usage needs, preventing tumor formation.
bioRxiv · Sep 24, 2025 · PreprintCell Biology