Judith E. Kimble

The paper shows that FBF-2, a PUF RNA-binding protein, maintains stem cells even when it cannot bind RNA, indicating that RNA-binding is not essential for its biological activity.

The paper identifies a ternary PUF complex in C. elegans that regulates germline stem cells by repressing and activating gld-1 mRNA through adjacent FBEs.

The paper investigates PUF RNA-binding protein partnerships with intrinsically disordered proteins in C. elegans germline stem cells, showing their role in RNA repression and self-renewal.

The paper edits Notch-dependent cis-regulatory elements in C. elegans to study their role in stem cell self-renewal and finds that element number and clustering affect gene expression and stem cell pool size.

The paper identifies genes that function redundantly with lst-1 or sygl-1 to maintain C. elegans germline stem cells through genetic screens.

The paper identifies tissue-specific MPK-1 isoforms in C. elegans and shows that the soma-specific MPK-1A promotes germline stem cell proliferation non-autonomously.

The paper improves a protein-mRNA tethering assay in C. elegans to study RNA binding protein function, finding that NOS-3 enhances reporter expression and mRNA stability.

The paper investigates how PGL dimerization is essential for P-granule assembly and mRNA repression in nematodes, identifying WAGO-1 as a key regulator.

The paper identifies two classes of active transcription sites (iATS and cATS) in C. elegans and shows their differential contribution to transcriptional output during development.

The paper identifies a PUF hub of four PUF proteins and two partners that drive self-renewal in C. elegans germline stem cells, explaining the milder defect in FBF mutants.

The paper identifies regions in the C. elegans LST-1 protein that mediate its function in stem cell self-renewal through interaction with the FBF RNA-binding protein.

The paper identifies gamete-specific and gamete-independent FBF targets in C. elegans germlines using FBF iCLIP data and clusters them into functional blocks.

This study examines niche signaling in male C. elegans germline stem cells, finding similarities in GSC maintenance despite sex-specific niche architecture.

This study characterizes the 3D architecture of the C. elegans germline progenitor zone and shows how germ cells divide and differentiate along its folded structure.

The paper identifies FOG-3 as a Tob/BTG protein that forms polymers to regulate sperm fate in nematodes through RNA binding.