Reduction of Nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration
Leon Tejwani, Youngseob Jung, Hiroshi Kokubu, Sowmithra Sowmithra, Luhan Ni, Chang‐Woo Lee, Benjamin Sanders, Jong Seo Lee, Yangfei Xiang, Kimberly P. Luttik, Armand Soriano, Jennifer Yoon, Junhyun Park, Hannah J. Ro, Hyoungseok Ju, , Janghoo Lim
This study shows that reducing Nemo-like kinase enhances lysosome biogenesis and improves TDP-43 clearance, alleviating neurodegeneration in mouse models.
Journal of Clinical Investigation · Jun 29, 2023Peer-reviewedNeuroscience