The Ligand Preference of LRP1 is Regulated by O-glycans
John Hintze, Asli B. Topaktas, Thomas Daugbjerg Madsen, Shifa Jebari‐Benslaiman, Bethany H. Claridge, Silvia D’Andrea, Noortje de Haan, Lasse Holst Hansen, Rob Baars, Noé Quittot, César Martı́n, Zhang Yang, Sergey Y. Vakhrushev, Rebecca Louise Miller, Dudley K. Strickland, , Katrine T.-B. G. Schjoldager
The paper shows that O-glycans in LRP1's ligand-binding domains differentially modulate uptake of tau and amyloid beta, but not RAP or ApoE.
Science Advances · Jun 5, 2026Peer-reviewedMolecular Biology